A daily reading system for Davin

Learn through English.

One carefully selected English reading pack. Thirty focused minutes. Original sources, practical language and one piece of active output.

Latest reading

23 September 2026

C1AI × Trials × Validation30 min

When AI enters a clinical trial, what exactly are we validating?

Use a new EClinicalMedicine review to separate AI-as-intervention from AI-for-trial-operations, then connect intended use and decision impact to ICH E6(R3), E9(R1), and an AI-assisted TFL workflow.

Start reading PDF Markdown Open main source

2distinct roles for AI in trials

CTQrisk-based validation lens

1validation matrix to build

Designed for consistency

Less noise. Better signals.

Source-aware

Official and primary sources establish facts.

Personalised

Priority goes to AI, clinical research, SAS, CDISC and statistical programming.

Active

Every edition ends with retrieval, retelling or a professional speaking task.

September 2026

23 SepAI in trials: intervention vs operations and validation↗22 SepClinAgent: Thin MCP, Thick Skills for clinical programming↗21 SepGxP-Agent: process DAGs, ADaM automation and validation↗20 SepMedCP: agentic RWE, EHR tools and reproducible evidence↗19 SepClinAgent: source-aware trial retrieval and evidence paths↗18 SepOn-premise clinical AI agents: permissions, execution and auditability↗17 SepLLM trial audit: primary-outcome changes and endpoint lineage↗16 SepLLM adverse-event detection: disagreement as a safety-review signal↗15 SepSAP-to-code fidelity: silent errors and statistical QC↗14 SepEHR free text to analysis data: extraction, timing and provenance↗13 SepDefensible AI outputs: SCE governance, provenance and ClinAgent↗12 SepCDISC AI 2026: synthetic SDTM/ADaM, SAPs, TFLs and traceability↗11 SepSemantic metadata: why CDISC still matters for AI agents↗10 SepSingle pivotal trials: replication, robustness and TFL transparency↗09 SepMulti-agent trials: task autonomy, standards, blinding and accountability↗08 SepLongitudinal AI: preprocessing, external validation and data lineage↗07 SepReusable agent skills: procedural knowledge, context and deterministic checks↗06 SepMeaningful human oversight: approval fatigue, situational awareness and skill preservation↗05 SepWorkflow-aware benchmarking: state, evidence, tools and escalation↗04 SepFive-phase validation: from SP AI benchmark to production↗03 SepTrialGPT 2.0: from benchmark to deployable clinical workflow↗02 SepDigital endpoints: continuous sensor streams, derivation and provenance↗01 SepLLM semantics and deterministic TFL validation↗

23 Sep Markdown 23 Sep HTML 23 Sep PDF